KMID : 0370219810250030101
|
|
Yakhak Hoeji 1981 Volume.25 No. 3 p.101 ~ p.108
|
|
Study on the Absorption and Excretion of Capsaicin in Rabbits
|
|
±è³«µÎ/Kim ND
¹ÚÂù¿ë/Park CY
|
|
Abstract
|
|
|
Quantitative determination of capsaicin in biological fluid was investigated. The pharmacokinetic study of capsaicin in rabbits was performed by high-pressure liquid chromatography, equipped with a microparticulate reversed-phase column and a fixed wavelength detector. Elution was carried out using methanol-water(70:30). It allows the quantitative determination at 8~400ng level. When single dose of capsaicin(4mg/kg) was given to rabbits intravenously, the elimination phase was extremely short with average half-life to 17.35 minute. Urine excretion of capsaicin itself during first 2 hours after intravenous administration (4mg/kg) was 0.004~0.04% of the administered amount. The maximum plasma concentration of capsaicin after oral administration (300mg/kg) was 4 X 1O-7g/ml at 40 minutes. The LD50 of capsaicin in mouse was 0.40mg/kg (i.v.) and 47.2mg/kg (p.o.) which was determined by Litchfield and Wilcoxon¡¯¡¯s method, suggesting that the gastrointestinal absorption of capsaicin is poor.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|